Did You Know That Red Bull Has a Magazine With a 27

first_imgWhen you think Red Bull, you should think scale. Whether it’s selling more than 35 billion cans of an energy drink in more than 165 countries, sponsoring hundreds of athletes or producing a men’s lifestyle magazine that’s printed in five languages and delivers more than 2.7 million copies globally, Red Bull aims to do everything big.The Red Bulletin is the company’s print magazine iteration, and it began in 2007 when the company launched its media division, Red Bull Media House. Red Bull Media house produces a variety of content, from print to video to recorded music. However, The Red Bulletin was the company’s first formal standalone media product.It would be easy to dismiss the magazine as a content marketing play, however the business model and content tell a different story. The magazine’s revenue stream works just like most consumer magazines–subscription, newsstand and ad sales. And editor-in-chief of the U.S. edition, Andreas Tzortzis says that while content supports the parent company’s mission, it’s purpose is not just a tactic to sell more cans. “The kind of stories we do are so varied, which is one of the great challenges each month,” he says. “Because we cover stories from beyond the world of Red Bull, and increasingly that’s become our mandate, we have shifted away from branded stories and have begun to push the boundaries and explore the exceptional.” What he means is The Red Bulletin covers many of the same concepts and issues other lifestyle magazines are tackling, but instead tries to contextualize them from the brand and its consumers’ perspective.”We occupy many different spaces,” Tzortzis says. “We’re able to tell stories from other countries in the perspective of people living there. Whereas a lot of American magazines tell those stories from the perspective of an American in another country.”Tzortzis admits that The Red Bulletin borrows from a lot of different magazines in that it covers a number of lifestyle topics including sports, music and gear reviews. But he does say that he doesn’t see the magazine having a clear competitor. The magazine publishes on multiple platforms beyond print including a website and an app. It also develops videos to complement its feature stories. Nevertheless, print is still the magazine’s primary vehicle for reaching readers.”I have a soft spot for print, as does our founder” Tzortzis says. But he says there’s more to it than that. “Magazines can provide the context, we can slow down the story. So much of our world is quick-hit clips. But we place an emphasis on photography and our journalism, and I think that’s where print lives. Print lives in the ability to step back, to slow down the pace and provide the context. And for Red Bull Media House it provides the ability to branch out.” What Tzortzis means by “branch out” is that The Red Bulletin taps into a demographic different from its typical beverage consumer–specifically, men in their late 20s and into their early 30s. The magazine also recently redesigned its front of book section “Bullevard” under the direction of its new publisher Wolfgang Winter. The new design was developed in order to give the reader a “running start” to its feature well, according to Tzortzis. This is the magazine’s second design upgrade this year, after overhauling the back of the book in early 2013. And Tzortzis says to expect more upgrades in 2014.More on this topic Red Bull Magazine, “The Red Bulletin,” Priced at $4.99 a Pop Red Bull Media House Brings Its Magazine Online ESPN Relaunches Rise, Increases Circ to 1 Million Primex 2006: From E-Media to Virtual Proofing, Program Reflects a Conflicted Era The Red Bulletin Evolving into Traditional Magazine Martha 2.0: After Ad Turnaround, CEO Says ‘Survival’ Question Put to RestJust In Meredith Corp. Makes Digital-Side Promotions | People on the Move The Atlantic Names New Global Marketing Head | People on the Move Four More Execs Depart SourceMedia in Latest Restructuring PE Firm Acquires Majority Stake in Industry Dive TIME Names New Sales, Marketing Leads | People on the Move This Just In: Magazines Are Not TV NetworksPowered bylast_img read more

Pentagon Says Border Deployments Cost 534 Million Expects to Expand Role

first_img ADC AUTHOR Deployment of troops to the southern border is expected to cost at least $534 million by the end of September, the Pentagon said, according to The Hill. A DOD letter to Congress references $350 million for the National Guard mission and $184 million for the active-duty mission.DOD also announced Tuesday it has awarded nearly $1 billion in contracts to build the administration’s border wall.Assistant Defense Secretary Robert McMahon told lawmakers this week that any military construction projects to be defunded or delayed due to Pentagon funds redirected for the administration’s border barrier have not been chosen.“It’s a level of detail we are not down to yet, because today there is no requirement,” McMahon said, according to Military.com.The border deployment is also affecting readiness, Marine Corps Commandant Gen. Robert Neller told the Senate Armed Services Committee Tuesday. He said deployments have helped some service members such as pilots, military police and engineers, but others could see skills degrade.“One particular unit is doing a mission today that’s not part of their core competency,” he said. “For 60 days, they can handle that, but it will affect their readiness.”Acting Defense Secretary Patrick Shanahan said Tuesday he expects that the Pentagon’s border role will expand as the Department of Homeland Security requests more assistance, Military Times reported.Army Corps of Engineers photo by Brooks Hubbard IVlast_img read more

China reportedly halts applications for new game licenses

first_img Post a comment 0 Tags Share your voicecenter_img China’s media regulators have stopped accepting applications for new games.  Getty Images China is again pushing pause on video games as it works through a backlog of applications caused by an earlier halt to new game licenses. The country’s media regulators have stopped accepting new applications for commercial video game licenses, according to a Financial Times’ report published on Wednesday. Central regulators reportedly haven’t accepted applications since September. This comes after China in August halted the approval of new game licenses due to a “restructuring of power” in government agencies. While China’s media regulating agency, the State Administration of Press and Publications, reportedly resumed approving commercial game licenses in December, developers will have to wait for the current backlog to get approved in order for the license application process to move forward, according to Financial Times. The agency has reportedly approved over 500 games since December, including Tencent’s Perfect World Mobile, but new games will have to wait to debut.  Tencent, one of the biggest game developers in China, reportedly lost over $160 billion in market value in the first half of 2018, and smaller companies were struggling to survive, according to Bloomberg. China’s State Administration of Press and Publications didn’t immediately respond to a request for comment.  Gaming Politicslast_img read more

RBS initiates closure of branches to shut India banking business by yearend

first_imgConfirming reports that Royal Bank of Scotland (RBS) Plc would choose to wind up its India banking operations over seeking other exit options, the bank in statement on Monday announced it was closing down its corporate, retail and the institutional businesses in the country.”After examining a number of options for our banking business in India, we decided to wind down our corporate, institutional and retail banking businesses in India,” said RBS. It added that the bank will shut down all its 10 retail branches in India in a phased manner.Earlier in 2016, the bank had initiated its corporate and institutional businesses exit and also sold its onshore loans portfolio. Its offshore loan book and private banking business were sold last year, reported Mint.The Financial Times on April 12 reported that RBS’ decision to wind up was based on the country’s stringent regulations on acquisition of banking businesses within the country. “You are in limbo. Every day, the value is eroding until it becomes cheaper just to close down the operation,” a senior executive complained on India’s lengthy process for acquiring/selling banking entities.However, in a statement to Reuters, its chief executive Ross McEwan had said the decision to close its India business was a part of its overall global plan to sell or shut businesses in two-thirds of the countries it operates in. The company wanted to bring down operations to 13 countries from the existing 38. The bank had also held that it was not feasible for it to sell its India businesses in its entirety and that it would consider sale of individual parts, if not an outright winding up.Shuttering RBS’ banking operation will mean a loss of 700 jobs, according to FT. However, it added that RBS’ 13,000-strong back-end employees supporting global operations would continue to exist in India.RBS said in Monday’s statement: “We are committed to provide our employees with a range of support and will ensure that they are treated in a fair and transparent manner in line with RBS’ principles and local policies.”last_img read more

Alien researcher releases footage of UFOs hovering above Wasatch Mountains in Utah

first_imgYouTube: MavixxxConspiracy theorists have long been alleging that aliens from deep space used to visit earth regularly, and most of the time, they will be hiding near mountain ranges and underwater. Adding heat to their claims, an anonymous alien researcher known by the name ‘Mavixxx’ has released a mysterious video that shows two unidentified glowing objects hovering above the Wasatch Mountain ranges in Utah.After uploading the video of the bizarre UFO sighting on YouTube, Mavixxx claimed that the clip was sent to him by a user named Pana Rican. The conspiracy theorist also revealed that the alleged sighting happened on June 04, 2019. In the video which was shot in broad daylight, two unidentified flying objects, one pretty large when compared to the other was seen hovering silently above the ranges.In the same video, Mavixxx has also unveiled several other UFO sightings that happened in the past few months, and out of them, the most interesting one being a clip apparently captured from Edmonton, Canada. In the clip, a jet plane can be seen flying low, and in the meantime, a cylindrical UFO zipped past the flight at an amazing speed.The video uploaded by Mavixxx has already gone viral on the internet, and as of now, it has racked up thousands of views on YouTube. After watching the video, conspiracy theorists outlandishly claimed that these sightings are authentic proofs of alien existence. As per these conspiracy theorists, aliens are building secret bases on mountains, and the activities are carried out with the knowledge of the government and space agencies like NASA.These conspiracy theorists argue that NASA is intentionally covering up the secrets regarding alien life fearing public panic.”The first those are on the other side of those massive mountains and just too far to gain a visual but they are very big and there’s two. In a split second of the frame, I see a fighter jet In the upper right corner. Is there a base nearby?” commented Muttaxe444, a YouTube user.”Thank people like MAVI for creating youtube channels such as this, to tell the truth, that people yearn for,” commented Kalifornia Kid, another YouTuber.last_img read more

Former SC judge Amirul Kabir no more

first_imgAmirul Kabir Chowdhury. File photoFormer chairman of National Human Rights Commission and retired Supreme Court judge Amirul Kabir Chowdhury died at a city hospital on Tuesday evening. He was 78.The retired Appallate Division judge, Amirul Kabir, was admitted to Bangladesh Medical College Hospital due to old-age complications on 25 March, said his son-in-law Rajib Ahmed.Amirul Kabir was survived by a son and two daughters.His first namaz-e-janaza is scheduled to be held on Eidgah Mosque premises on Tuesday night.His last namaz-e-janaza will be held at Chandgaon residential area mosque in Chattogram after Zuhr prayers on Wednesday, according to family members.He will be buried there.last_img read more

StoneHill Group Recruits Business Development Manager

first_img Movers & Shakers StoneHill Group 2014-12-02 Tory Barringer December 2, 2014 516 Views in Headlines, News StoneHill Group Recruits Business Development Managercenter_img Share The StoneHill Group, a mortgage solutions firm headquartered in Atlanta, recently named mortgage industry veteran Patricia Hamilton as business development manager.Hamilton has more than 30 years of industry experience, 20 of which were spent at Freddie Mac, where she gained experience working with lenders of all sizes as national account manager. During her time at the GSE, she earned numerous company awards and oversaw the accounts of a diverse customer base that included some of the country’s top mortgage firms.More recently, Hamilton managed sales in the western territory for HomeBridge Funding, where she ranked as the company’s top salesperson for six straight months. Working for the StoneHill Group, she’ll operate in a similar position, managing sales and client accounts throughout the U.S. West.”With the mortgage industry’s need for domestic loan quality help growing by the day, we’re thrilled that Pat is joining our team,” said David Green, founder and CEO of the StoneHill Group. “Besides having experience working closely with many different mortgage bankers, she is gifted at both sales and providing excellent customer care, which fits perfectly with our company culture. We are confident that current and future clients will be in great hands.”Commenting on her new role, Hamilton praised the StoneHill Group’s reputation for helping businesses develop stronger, safer, and more profitable mortgage operations through its range of offerings.”I look forward to helping West Coast mortgage lenders achieve improved loan quality, so they may find increased success in 2015 and beyond,” she said.last_img read more

Rep Lilly hosts Ottawa County United Way president for State speech

first_img Categories: Lilly News,Lilly Photos,News,Photos 18Jan Rep. Lilly hosts Ottawa County United Way president for State speech State Rep. Jim Lilly, R-Park Township, welcomed Patrick Moran, president at the Greater Ottawa County United Way, as his guest for the State of the State address in the state Capitol Tuesday.Rep. Lilly recently took his oath of office to represent western Ottawa County at the state House of Representatives.“I’m honored today that Patrick was able to join me as my guest in Lansing,” said Rep. Lilly. “Our governor is known for encouraging collaboration and I cannot think of a local organization that better embodies that effort in our community than the Ottawa County United Way.  I’m very encouraged by their commitment to regional partnerships as evidenced by their recent announcement of a shared service agreement with the Allegan County United Way.”Rep. Lilly and his wife Sarah have been involved in various volunteer capacities with the Ottawa County United Way for numerous years.  He has served as both a member and a chair on a number of the organization’s community investment panels and as a Lighthouse Leadership co-chair for the organization’s annual fundraising campaign.His wife Sarah, a local Realtor, is currently serving a term as the president of the Ottawa County United Way’s board of directors.  Rep. Lilly said he “feels blessed to welcome someone like President Moran, who has dedicated over 10 years to this beloved organization.“I hope to hear Governor Snyder address the economic progress Michigan has made in recent years, but also highlight the areas where we still need to invest to maintain that growth within our state,” said Rep. Lilly.“It was wonderful to have Patrick Moran in the Capitol to hear the governor’s message as we all work together for Ottawa County,” said Rep. Daniela García, R-Holland.PHOTO INFORMATION: State Rep. Jim Lilly, R-Park Township, and State Rep. Daniela García, R-Holland, welcomed Patrick Moran (left), president of the Greater Ottawa County United Way, for the State of the State speech at the Capitol on Tuesday.last_img read more

In This Issue   Currencies look tired and worn

first_imgIn This Issue. *  Currencies look tired and worn out. *  Singapore inflation increases! *  U.S. data is ugly. *  Chuck retracts his comments on Poland. And Now. Today’s A Pfennig For Your Thoughts. RBNZ Hikes OCR! Good Day! . And a Tub Thumpin’ Thursday to you! I’ve got a ton of stuff to talk about today, so get your cup of coffee, and something to nibble on (my fave would be a cheese Danish!), and sit yourself down, for this is going to be an interesting ride today. Now, if I can just remember all the stuff I wanted to talk about today! UGH! Funny, I can hear a song for the first time in 30 years, and remember the lyrics, but I can’t remember what happened 10 minutes ago!  Oh, well, I guess I should get worried if I end up forgetting those lyrics, eh? Reminds me a great 70’s song, by the Pousette-Dart Band. Amnesia.  I hope that it’s only amnesia, believe me I’m sick but not insane. Front and Center this morning, the Reserve Bank of New Zealand (RBNZ) surprised me and the markets for that matter, by hiking their Official Cash Rate (OCR) by 25 Basis Points (1/4%) last night. I wasn’t surprised that the RBNZ hiked the OCR, I was surprised that they did it rate hikes at back to back meetings.  Back to back, belly to belly, I don’t give a dang ’cause I’m stone dead already, the Zombie Jamboree! I had told you long ago, and before the first rate hike by the RBNZ in March that I expected the RBNZ to hike the OCR 3 times this year, adding a total of 75 Basis Points (3/4%) to the OCR. Well, there’s two down, one to go!  I’m feeling pretty confident that the 3rd rate hike will be coming, maybe not next month, but coming nonetheless, because the RBNZ remained hawkish in their statement last night. In fact, I’m so confident now, I’m going to be like a cheesy infomercial and tell you: That’s Not All! If the RBNZ acts right away, they might be ready to hike rates another 50 Basis Points (1/2%) before summer is over!  The New Zealand dollar / kiwi got a boost from the rate hike news, and the subsequent hawkish statements by the RBNZ, but this morning kiwi is flat, and waiting for the U.S. markets to get a view of the new level for the OCR in New Zealand. I think that with rates starting so low in New Zealand, that these first two rate hikes have almost brought rates back to a better starting point, and IF, (that’s a BIG IF) the RBNZ does hike two more times it will bring the OCR to 3.5%… Still quite low for New Zealand, but over 300 basis points better than the U.S., Japan, and Eurozone. nothing to stick your nose up in the air over. OK. The currencies as a whole look tired this morning, and all either flat or down a shade, and wouldn’t you know it, China allowed an appreciation in the renminbi / yuan overnight. Moving in an opposite direction than the other currencies.. Strange but true..  And Gold is still stuck in the mud below $1,300. Well, one of my fave currencies, because of the way it is used to combat inflation, instead of arbitrary interest rate adjustments, The Singapore dollar / Sing $, should be getting the wink and nod from the people who set the trading bands on the currency, the Monetary Authority of Singapore (MAS), soon. Why you ask? Well, Sing inflation moved higher in March by 1.2% VS last year.  Yes, I think that while inflation in Singapore seems to be under control, you can’t ignore a move from .4% in Feb, to 1.2% in March.  History shows us that the MAS is very diligent in maintaining price stability in Singapore, and knowing this, I would expect to hear that the MAS widened the trading band for the Sing $, very soon. Proving once again that the bad weather card is something that will be used when necessary. Canada printed their Feb, yes that’s right, Feb Retail Sales report yesterday.  Retail Sales for Feb rose the expected amount of +.5%, which follows a revised .9% gain in January.  You might recall,  that originally, Retail Sales in January for Canada printed at +1.3%, so the .9% revised number is a downward revision.  So, even Canada plays this game, folks. And they don’t have to!  Canada is a sound financial, hardworking country, they don’t need to play games with data! Any-old-way you roll the dice, the data was not good for the Canadian dollar / loonie. I did see a write up from one of the writers at Agora that touted the Canadian dollar as a buy.  He based it all on a recovery of commodities.  And that’s a great place to start, for the loonie is considered a Commodity Currency, and in the past has responded favorably to rallies in commodities. So, I guess the question would be.. Do you believe in a Commodities Rally? For if you do, you might want to look to the loonie in addition.. Well.. Shiver me timbers! I must make amends! Yesterday, I told you how I was watching the Polish zloty and liked the economic and fiscal performance in Poland. I had a dear reader send me a note and ask me if I were crazy? “Didn’t you see that Poland confiscated private pension funds?”   I was shocked! Because NO, I had NOT seen that story reported anywhere!  But this dear reader thought to tell me where she saw this (Thanks Lynn!) and sure enough there it was on zerohedge.com for all the world to see! OK. first let me set this up for you. Poland has a hybrid pension system: mandatory contributions are made into both the state pension vehicle, known as ZUS, and the private funds, which are collectively known by the Polish acronym OFE. Bond make up half the private fund’s portfolios, with the rest company stocks.. The Polish Gov’t called this, what I’m about to explain as “an overhaul”.  I’ll let you decide what you would call it, but I wouldn’t use the word “overhaul”! “On Wednesday, Prime Minister Donald Tusk said private funds within the state-guaranteed system would have their bond holdings transferred to a state pension vehicle, but keep their equity holdings.  The funds would effectively be left with only the equities portions of their assets, even this would be depleted, and there will be uncertainty about the number of new savers joining. But why is Poland engaging in behavior that will ultimately be disastrous to future capital allocation in non-public pension funds (the type that can at least on paper generate some returns as opposed to “public” funds which are guaranteed to lose)? After all, this is a last ditch step which no rational person would engage in unless there were no other option. Simple: there were no other option, and the driver is the same reason the world everywhere else is broke too – too much debt. By shifting some assets from the private funds into ZUS, the government can book those assets on the state balance sheet to offset public debt, giving it more scope to borrow and spend.” See what happens when a Gov’t gets pushed against a wall by debt? That couldn’t happen here, right?  Ahem. think again. Oh, and by the way, I would call this confiscation. plain and simple. Well, since I came in this morning, Gold has dropped another $5 to $1,278.00. That’s just not right folks. But it is what it is. There’s nothing I can do about it, and I learned a few years ago that I can rant and rant about something, but it doesn’t change it, and only gets my blood pressure boiling, which isn’t a good thing! If all things were equal, and there was no such thing as price manipulators, I would say that this current level for Gold looked to be a good opportunity to buy it cheap.  Long ago, and far away, I first began to tell you all how I viewed China’s hoarding of Gold as essential to their plan to either 1. Back their currency with a percentage of Gold when they decide to float it,  or 2. Have enough Gold to make the rules when everything goes to hell in a hand basket, and countries sit down to see who has the Gold. I lean heavily on the 1st of those two options, and have for some time now.  I’ve always thought that China would be the 1st to back their currency with Gold again. Then last year, I started telling you about how Russia was also hoarding Gold.  Well, a recent article on Russia, states that “The Central Bank of Russia has made a subtle, yet serious threat against the lynchpin of the American Economy, the U.S. dollar.  According to Russian media, The Central Bank just released a new logo, which is a Gold ruble.” So, is Russia planning on moving ahead of China in this race to have a Gold backed currency?  Sounds like it, but. I would still think that China is more prepared to do this than Russia. However, having said that, the urgency to back the ruble with Gold seems to be fueled by Russian President, “Putin, who has made it quite clear that any attacks on the Russian economy will be answered in with retaliations of their own.” I think that we should be taking this treat seriously folks. I know that symbolism is huge to Putin.  So, now we have two large countries, heading toward backing their currency with Gold. The tide is changing on the dollar’s hold as reserve currency folks. When will everyone else wake up and smell the coffee? The Aussie dollar (A$) is taking another shot to the mid-section this morning, after being down for the count yesterday. The soft CPI (consumer inflation) report from Australia on Tuesday night, has really caused the A$ to look for a place to hide, but finding no place to hide, it takes its punishment for having weak inflation. Now, how smartless does that sound to you? Doesn’t inflation eat away at a currency’s value? Of course it does! So, what’s the frequency Kenneth?  The markets are convinced that Central Banks can control inflation, so with that thought, the markets want to see inflation in the countries rise, so that interest rates can rise. It’s a strange and dangerous game the markets are requiring the Central Banks to play right now. For it is my opinion that Central Banks are always late to the party, and always playing catch-up with runaway inflation. Well, the U.S. Data Cupboard printed some ugly data yesterday. I’m sure you didn’t hear about any of it, and if you did, I’m sure the “bad weather” card was played.  First, we had Mortgage Applications for last week, drop by -3.3%… Then we had the private firm Markit print their U.S. Manufacturing Index, and saw it weaken a bit for April.  and then the New Home Sales, took the Nestea Plunge in March.  Sales of new single-family homes in the U.S. fell -14.5% VS Feb. to an annualized 384,000 units, in March. The lowest level of sales since July 2013. This one hurt, for the markets were expecting an increase to 450,000 annualized units. That’s a HUGE difference folks, and I think reflects the fears out there that interest rates are going higher in the near future. And then finally today, the first piece of market moving data for this week will print. Durable Goods Orders for March will find its way to the Data Cupboard’s docket this morning. And in the background, we’ll see something just as important, but pushed to the background by the markets, Capital Goods Orders & Shipments. For What it’s Worth.  Man, I feel like today’s letter is a collection of For What It’s Worth ideas! But, fear not, dear reader, for I will still bring you a FWIW section/ story for today.  And it’s a real treat this morning, for I have a snippet of an interview with my fave analyst / writer right now, Grant Williams.  I’ll set this up first.  Grant Williams is talking about how in the West the people don’t understand Gold, but in the East they do. But that’s not the Achilles’ heel that he sees for the West.  let’s listen in..  Oh, and I found this on Kingworld.com. “I think the Achilles’ heel of the West is the politicians.  I think they are inept and they are focused on all the wrong things.  And the danger of a miscalculation on a political level by a very inept group in the West against the very smart operators that you have in the East, is potentially a big Achilles’ heel. Gold is certainly something that, despite protests by Western central bankers to the contrary, they do think a lot about and it is something they watch.  But if they did the right thing, the gold price would go higher.  When I say the right thing, I mean that if they converted more reserves in the West to gold, yes, the price would go higher. And when you look at the incredible problems facing the West, with the sheer amount of the debt, watching the price of gold soar is not something they can allow if they are trying to print massive quantities of money.  If they allow the price of gold to head significantly higher, then the underlying inflation in the West is going to become far more evident, and that’s something that doesn’t play well politically. So I think the political class is by far the most dangerous thing that the West has to face at the moment.  And we are in a year where there are going to be elections all over Europe, midterms in the United States, so the political landscape is where we are going to see some real fireworks this year.” – Grant Williams Chuck again. I’ve told you all before that Grant Williams writes a newsletter called “Things that make you go hmmm”. It’s the one newsletter I get, and I get a boatload of them, that I open up and read the minute it hits my email box!   Comfortably Numb was just playing on the IPod, and that’s what we’ve all become, regarding debt in this country. To recap. The currencies look tired and worn out, and for the most part are either flat or down a bit this morning, except the renminbi / yuan which saw an appreciation overnight by the Chinese Central Bank. The RBNZ hike rates last night, which surprised Chuck for the timing not the actual rate hike. Chuck now believes his original forecast of 75 Basis Points of rate hikes from the RBNZ was too conservative, and has now boosted it to 100 Basis Points before summer is over. 50 down, 50 to go!  Chuck puts his tail between his legs on a statement he made about Poland, Singapore inflation jumps higher in March! Currencies today 4/24/14. American Style: A$ .9270, kiwi .8575, C$ .9075, euro 1.3825, sterling 1.6785, Swiss $1.1325, . European Style: rand 10.5650, krone 5.9860, SEK 6.5590, forint 222.90, zloty 3.0315, koruna 19.8560, RUB 35.68, yen 102.40, sing 1.2570, HKD 7.7530, INR 61.08, China 6.1589, pesos 13.03, BRL 2.2215, Dollar Index 79.80, Oil $101.87, 10-year 2.71%, Silver $19.09, Platinum $1,398.25, Palladium $785.56, and Gold. $1,278.15 That’s it for today. Long winded today, eh? Well, I think I recalled everything I wanted to talk about and then some! Little Feat are playing Dixie Chicken right now on the IPod.  I love to sing along with that song! I’ve seen the bright lights of Memphis. And the Commodore Hotel. And underneath a street lamp, I met a southern belle. see what I mean? Well, our Blues lost their mojo these last two games, and head back to St. Louis for Game 5, tied 2-2 in games won. I hope they find the magic here on home ice! And Cardinals pitcher Michael Wacha struck out 9 Mets batters for his first 9 outs last night, but still lost the game. UGH!  So, another bad night for St. Louis sports!  Alex picked up his tux last night, his senior prom is this Saturday night. I told him he could drive my car if he wanted to, and he was all over that in a heartbeat! Kathy’s baby boy is getting ready to graduate High School and move on to college, I have a feeling she’s going to be emotional about this. but maybe not. OK. once again, I’ve carried on too long. so for that I apologize. Now let’s go make this a Tub Thumpin’ Thursday! Chuck Butler President EverBank World Marketslast_img read more

Recommended Link

first_imgRecommended Link Recommended Link World-renowned crypto expert: “I’m revealing my cryptocurrency investment secret” For the next few days, the crypto expert who’s been called “The Oracle” of cryptos on the internet and is followed by over 100,000 people across the globe is revealing his proprietary investment strategy. It’s already helped an “average Joe” named Paul turn $500 into just under $140,000… click here to see what it could do for you. • Tesla’s stock plummeted 7% on the news… You can see that big drop in the chart below. Tesla’s now 22% off its recent highs. You might be tempted to buy it now. But that would be a huge mistake…• Tesla isn’t cheap by any stretch of the imagination… It still trades at a price-to-sales (P/S) ratio of 4.8. That makes it more than twice as expensive as the average large-cap U.S. stock. More importantly, it’s 13 times more expensive than competitor General Motors. And it’s 15 times more expensive than Ford, another major U.S. carmaker. There’s absolutely no reason why Tesla should be this expensive. The company has never once booked a profit. Instead, it’s lost about $4.3 billion since it was founded 14 years ago, and that’s despite massive government handouts. As if that weren’t bad enough, Tesla’s bleeding cash. It’s burned through $2.6 billion in cash in just the last two quarters…and more than $10 billion since it was founded in 2003. If this keeps up, Tesla could run out of cash within the next 12 months.• This is a serious problem… But Musk and Co. aren’t actually trying to fix it. Instead, they’re trying to “paper it over.” According to Bloomberg, Tesla has issued new stock eight times in the last seven years. That hurts existing shareholders. But it gets worse. Tesla also borrowed obscene amounts of money just to keep the lights on. Back in August, it issued $1.8 billion in “junk bonds” to finance the production of its Model 3 vehicles. This isn’t just unsustainable. It’s a recipe for disaster. In fact, I wouldn’t be surprised if Tesla’s stock goes down in flames the next time it reports a “hiccup.” So, continue to avoid Tesla like the plague. You may even want to consider shorting (betting against) TSLA. Just understand that shorting is risky. So, make sure you know what you’re doing before you put this trade on.Regards,Justin Spittler New Orleans, LA November 6, 2017 P.S. I recently wrote about a better way to profit from the electric car revolution. You can read about it here. Reader MailbagRecently, we shared an interview with Doug Casey’s longtime friend and colleague Bill Bonner: “Bitcoin—Better Money Than Gold?” Today, readers weigh in… It’s only as good as the government that rules over it! Fools rush in where wise men never go… Remember?—Howard By Justin Spittler, editor, Casey Daily Dispatch“Tesla’s shareholders will be in for a rude awakening… Its share price could soon fall off a cliff.” I issued this warning on October 5. But I’m sure some people thought I was crazy for saying this. That’s because Tesla’s stock was up 66% on the year…and more than 900% since the start of 2013. It was one of the hottest stocks on the planet. But it shouldn’t have been.After all, it’s not like Tesla’s raking in cash. It’s never booked a yearly profit in its history.• Instead, Tesla was rallying because Elon Musk is a “visionary”… Musk is the founder and CEO of Tesla. But unlike most CEOs, Musk doesn’t care about quarterly profits. He only cares about changing the world. He wants everyone to drive electric vehicles (EVs). He wants to put solar panels on every home in the United States. And he wants to colonize Mars. These are wildly ambitious goals. But they make for a great story.• That’s why Tesla has some of the most loyal shareholders on the planet…It’s also why many of its investors ignore problems that would send most people running for their lives. Just consider how Tesla shareholders reacted to awful news last month. Regular readers know where I’m headed with this. On October 2, Tesla announced that it had produced just 260 Model 3s, its first mass-market vehicle, during the third quarter. Musk had promised investors 1,500 vehicles. That’s an 83% shortfall. • Normally, a stock crashes when a company whiffs this bad… But Tesla rallied on the news. Again, that’s because Tesla shareholders don’t care about profits, cash flows, or debt. They only care about Musk’s dreams. But here’s the thing. Dreams don’t last forever. Eventually, you must wake up and face reality. That’s why I urged readers to avoid Tesla on October 5. Tesla will miss its production goal again… Tesla’s shareholders will be disappointed again. And next time, they might not be so forgiving. And that’s exactly what happened…• Last Thursday, Tesla reported its worst quarterly results ever… The electric carmaker lost $619 million last quarter. That’s nearly double the $336 million loss it suffered during the second quarter. That’s a staggering loss. But it looks like things will get even worse for Tesla. After all, the company just laid off about 700 employees. That’s about 2% of its workforce. Tesla’s also struggling to ramp up production of its Model 3 vehicle. Last month, Musk said Tesla would produce 5,000 Model 3s per week by the end of the year. But now he’s saying they won’t hit that mark until early 2018, at the earliest. He also scrapped the company’s longtime goal of eventually producing 10,000 Model 3s per week. — In Case You Missed It…Last week, cryptocurrency investing expert Teeka Tiwari hosted the largest webinar in our industry’s history. More than 80,000 fellow readers tuned in to learn how Teeka has found his readers gains as high as 1,626%, 3,274%, and even 21,127% in the cryptocurrency market. If you missed it, Teeka agreed to show a replay of the webinar. Watch it for yourself right here. — Teeka’s new cryptocurrency prediction could make you a fortune by January For the next few days only, crypto expert Teeka Tiwari is revealing his next big cryptocurrency prediction for 2018. Last year’s prediction was spot on… Those who followed his best ideas had the chance to turn a small stake into nearly $200,000. Click here to be among the first to hear his latest. I have one fundamental question—most of the banks are prohibiting sending money from our account to buy cryptocurrencies. Then how to pay for it?—Mukeshlast_img read more

The death of a former major league baseball player

first_imgThe death of a former major league baseball player in his native Venezuela this week is renewing concerns over the Latin American country’s growing health crisis amid ongoing economic and political turmoil.Marcos Carvajal, a 34-year-old former pitcher for the Colorado Rockies and Florida Marlins, died of pneumonia on Tuesday. He fell sick in December, but the antibiotics needed to treat the illness were hard to find. Drugs for Carvajal eventually were sent from abroad but he relapsed, returned to the hospital on Monday and died the next day. The Pharmaceutical Federation of Venezuela estimates the country is suffering from an 85 percent shortage of medicine amid an economic crisis also marked by severe hyperinflation and food scarcity.The entire Venezuelan health care system is on the verge of collapse, says Francisco Valencia, head of the public health advocacy group Codevida. Some hospitals lack electricity, and more than 13,000 doctors have left Venezuela in the past four years in search of better opportunities.”They don’t give food to the patients in the hospital,” Valencia tells Here & Now’s Peter O’Dowd. “They don’t have the proper medical supplies to take care of the people who go to the emergency [room] like gloves, like every basic thing they need for an emergency.”According to the pharmaceutical association, there is also a 90 percent deficit of other medical supplies and drugs used to treat more serious conditions like cancer.The shortage has forced Venezuelans to go looking for medicine on the black market, Valencia says. Even if they find the right medicine, which is often smuggled from Colombia and Brazil and could be expired, most people can’t afford it.The crisis affects Valencia personally, who relies on medication for a kidney transplant.”I haven’t received my medicine since August last year,” he says. “Right now, I’m taking medicines that [have] expired, and my transplant is at risk.”Venezuela’s President Nicolas Maduro has refused to accept humanitarian aid, blocking shipments of medicine and first aid supplies. Government data shows infant mortality rose by 30 percent in 2016 and malaria infections shot up 76 percent, Reuters reports.”So most countries when they’re hit by a crisis, they’re taking aid from other countries, from NGOs,” Associated Press reporter Hannah Dreier told NPR in 2016. “But Venezuela keeps refusing to take donations that other countries are offering and is actually turning back shipments of donations that people have given in places like the U.S., not letting medicine in.”Drug prices have skyrocketed along with those for food and other basic necessities. The International Monetary Fund predicts inflation will soar to 13,000 percent this year and the economy will shrink by 15 percent.Earlier this week, the government announced it would abandon one of its two official foreign exchange rates, which had been used for food and medicine imports, Reuters reports. The policy change could encourage businesses to import more goods, but critics say it won’t be very effective due to the lack of hard currency in Venezuela.The elimination of the exchange rate was “a step in the right direction because it helps correct foreign exchange distortion,” Asdrubal Oliveros of local consultancy Ecoanalitica told Reuters. “But without dollars, things will continue to be more complicated.”Since the collapse of Venezuela’s oil-rich economy in 2014, the country has struggled to raise hard currency. The monthly minimum wage for many Venezuelans is now equal to $3, according to the AP.Maduro blames the country’s growing crisis on foreign economic sanctions, claiming that the U.S. is leading an effort to wipe out socialism in Venezuela, according to Reuters. Presidential elections are set to be held by April 30, which is much earlier than usual, but Venezuela’s pro-government Supreme Court last week banned the main opposition party from running. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

When Maddy Nadeau was a toddler her mother wasnt

first_imgWhen Maddy Nadeau was a toddler, her mother wasn’t able to care for her. “I remember Mom was always locking herself in her room and she didn’t take care of me. My mom just wasn’t around at the time,” she says.Every day, her older sister Devon came home from elementary school and made sure Maddy had something to eat.”Devon would come home from school and fix them cold hot dogs or a bowl of cereal — very simple items that both of them could eat,” says Sarah Nadeau, who fostered the girls and later adopted them.The girls’ parents struggled with drug addiction, and for several years, the sisters moved in with different relatives and eventually, foster homes. Nadeau says when they arrived at her home, both girls were anxious and depressed and had a hard time focusing in school — especially Maddy, who had been exposed to drugs in utero.”That makes it very difficult for her brain to settle down enough to do more than one task at a time,” Nadeau says.The Nadeaus live on Cape Cod, which has some of the highest numbers of deaths due to opioid overdoses in Massachusetts. It’s also where a growing number of schools are hiring treatment counselors to work with teachers and their students whose families are battling addiction. The counselors work at the schools but are employed by Gosnold, the largest provider of addiction services on the Cape.In October, Congress authorized $50 million a year for the next five years to fund mental health services to help school districts treat students who have experienced trauma due to the opioid epidemic.And an increasing number of school districts across the country are starting not only to screen and treat at-risk kids for opioid addiction, but also access mental health counseling specifically for students whose families and communities are consumed by opioid abuse.”Schools have more kids who cannot access the learning environment,” says Sharon Hoover, co-director of The National Center for School Mental Health at the University of Maryland School of Medicine. Children are “suffering from family substance abuse and schools are feeling the burden.”Hoover says bringing counselors and psychiatrists into the schools is an effective approach.”This is considered a preferable model of care,” she says. “The kids show up for treatment services because they’re not relying on a family member to take them somewhere in the community.”These programs are new, but data shows that school counseling for kids at risk for substance abuse leads to less absenteeism and better school performance.In Massachusetts, the schools using the Gosnold counselors report that their students are doing better academically and emotionally.Sarah Nadeau says that has been the case for both Maddy and her older sister, who are leading more stable lives since they began seeing the Gosnold counselors at school every week.”Their day runs smoother. They can get out their anxiety while they’re in school instead of bottling it up, and then go back to class and continue learning,” she says.K’yan Kelly is a Gosnold counselor who works at Lawrence Middle School in Falmouth, Mass. She sees Maddy Nadeau at least once a week.She recently increased the number of days she works at the school because she says so many children are experiencing the chaos of addiction, including the fear that their parents might not survive an overdose.”The unknown of whether a parent will live is a certain kind of trauma,” says Kelly. Also, “if you are a child who has experienced trauma, school itself can have a lot of demands.”The counselors are also there to support the teachers, who must navigate how to educate kids whose families are consumed by addiction.”It’s a lot. You’re dealing with addiction, you’re dealing with trauma, you’re dealing with loss and that’s what they’re up against, a lot of these kids,” says Carolyn Alves. Alves has been teaching for 17 years, most of them at Lawrence Middle School.She has seen an increasing number of students who are living in foster care or have moved in with other family members because their parents are dead, in jail, or struggling with active addiction.”You know that what they need is a lot bigger than what you can give to them as their teachers,” she says.Each school pays Gosnold a fee for its counselors. Private insurance covers the student’s individual sessions. If insurance won’t cover the therapy, Gosnold will absorb the cost. Last year, 17 schools on Cape Cod used Gosnold counselors, this year there are more than 50 schools offering these services to students throughout Massachusetts.”I wish that more schools offered it because the epidemic is everywhere,” says Sarah Nadeau. “For a lot of these kids, school is the only place that is stable. They get their lunch here, they get their education here, so why not give them their support while they’re here at the school?”This story was produced in partnership with The Hechinger Report, a nonprofit, independent news organization focused on inequality and innovation in education. Copyright 2018 NPR. To see more, visit https://www.npr.org.last_img read more

5 Content Marketing Lessons From SNL in the Age of Trump

first_img Director of Sales and Marketing at Strategic Sales & Marketing Register Now » 5 Content Marketing Lessons From SNL in the Age of Trump Guest Writer Add to Queue Free Webinar | July 31: Secrets to Running a Successful Family Business Learn how to successfully navigate family business dynamics and build businesses that excel. –shares Content Marketing Opinions expressed by Entrepreneur contributors are their own. Take today’s key issues and create meaningful content for your customers. 4 min read Image credit: Will Heath | NBC | Getty Images February 27, 2017 Whatever you think of his politics, President Donald Trump has been great for comedy. Saturday Night Live is having a revival of popularity as its hard-hitting satire and perfectly casted actors — like Melissa McCarthy’s hilarious portrayal of White House spokesman Sean Spicer and Alec Baldwin as Trump — speaks to the country’s latest concerns about the various chaos and insanity emerging from Trump’s administration. Related: Is Vocally Opposing President Trump Risky Business?What can other content creators and marketers learn from SNL’s recent resurgence of Trump-related success? Seize upon key issues and crucial conversations.Trump’s presidency is the biggest story in recent political history, so this is an easy one for SNL. Everyone in the national media is talking about Trump all the time. But what about your business or your industry? What are the key issues that your customers are worried about and focusing on? Don’t assume that you know the answer. Use Twitter as a listening tool to see which keywords and topics are trending for your industry and your key audiences. Then you can create content that speaks directly to those areas of concern.  Slay sacred cows.SNL is not afraid to be irreverent, even offensive, toward the most powerful people in Washington. What is the biggest controversial topic/issue in your industry? What are the things that people in your industry should be saying? What stands should they be taking that they are not? What is the elephant in the room or the emperor with no clothes? Find these opportunities and create content that speaks to those issues. Build a reputation as a truth teller. Related: What to Consider Before Your Brand Takes a Stand PoliticallyRally your base.SNL is probably not going to win many fans among Trump’s supporters, but they’re focusing instead on getting a bigger share of fans from the large percentage of Americans who are opposed to Trump. Don’t be afraid to be controversial or even polarizing. Sometimes it’s better to speak passionately to the people who are most enamored with your brand, even at the risk of not appealing to lots of other people. SNL is rallying a big audience of people who are not Trump supporters — and SNL’s ratings are up! In content marketing on TV, it’s often better to have a passionate and lucrative niche following than to fail to appeal to a mainstream mass audience that no longer really exists. Make unconventional choices. McCarthy was cast as White House spokesman Sean Spicer — and her performance was brilliant — but the choice of a woman to play Spicer was also oddly inspired and unexpected. Don’t be afraid to be unconventional. Keep trying new things and elevating new voices within your company. Your content strategy doesn’t have to look like the usual suspects. But stay focused on quality.SNL is having a resurgence of popularity as people tune in to try to get some laughs out of our latest national political news, but even Trump’s biggest opponents won’t want to watch if the show’s not funny. SNL can’t become just a strident platform for anti-Trump statements; it still needs to be a comedy show first and foremost that makes people laugh. In the same way, content marketing can’t be just a stunt or a gimmick or push an agenda. You need to have a foundation of insight and quality that keeps people coming back. Related: How 10 Brands Thoughtfully Chimed In on President Trump’s InaugurationWho knows what will happen during Trump’s presidency, but SNL is leading the way for a vibrant, engaging, no-holds-barred national conversation about politics. This fearless spirit is something that all content creators and content marketers can try to emulate in our own work. Next Article Gregg Schwartzlast_img read more

With HomePod Apple Just Wants to Shake Things Up for Now

first_img Apple’s HomePod speaker is a depth charge dropped into the ocean where Google Home and Amazon Echo sail. At $349, it’s not going to dominate the voice assistant world. But for Apple to achieve its goals, the HomePod just needs to keep the waters rough enough to make its competitors seasick.There are a bunch of weird things about Apple’s HomePod announcement. First, Apple doesn’t like to announce products six months in advance. And while the iPhone and iPad are expensive, they’re not double the prices of rivals. The HomePod is also being sold as a music device above all else rather than virtual assistant. One interpretation is that Apple isn’t going after competing voice assistants but the midrange, wireless multi-room speaker market; the domain of companies like Sonos, Bose and Logitech. Yes, those companies have $200 options, but the Sonos Play:3 costs $299, and the Bose SoundTouch 20 costs $350. Those companies have been slow to adopt the kinds of flexible voice capabilities we’ve seen on Echo and Google Home, and they tend to appeal to a higher-end consumer who thinks the Amazon and Google products look and sound cheap.But I think Apple’s strategy is a little trickier than that. The midrange speaker market is in fact ripe for disruption, and I think Apple’s correct to assume that people who have expensive speakers probably have an iPhone. But by announcing the HomePod six months in advance, Apple’s also trying to draw developer attention away from Alexa and Google Home, making sure that it’s in second, not third place in the eventual war of the voice assistants.Second place is a very comfortable place for Apple, because it’s focused on profit share rather than market share. In a battle between Apple and Amazon, it’s easy enough to see a repeat of the iOS/Android war, where Echo speakers eat up the bottom end of the market while Apple reaps profits at the top. Amazon actually wouldn’t mind this, as (like Google with Android, but not like Android phone makers) its business isn’t dependent on making a profit from hardware.Developers can only handle two platforms.Platforms need developers, and we’ve seen over and over that the tech world is capable of supporting two — not three — platforms in most areas.On the desktop, it’s Mac and Windows, not Linux. On phones, it’s Apple and Android, not BlackBerry 10 or Windows Phone. On high-end tablets, increasingly, it’s Windows and iOS, with Android shunted down to the low end. Sure, the third platform often manages to hang on as a niche, but the two major ones dominate the market. Developers just don’t seem to have the resources to split their attention more broadly.Right now there are three players in voice assistants: Apple, Google and Amazon. Apple is coming late to the game, but it understands the value of not being third. And as it implied by focusing on music in its presentation, SiriKit is way behind the competition in attracting developers right now.Apple needs to get SiriKit into the conversation and to make sure Google and Amazon don’t lock down voice-assistant developers, which could definitely happen in the next six months. By announcing the HomePod now, Apple throws a bit of confusion into that community; should developers keep their powder dry?Google is likely to suffer more than Amazon from this, because Amazon has a lot of third-party partners and an already vibrant developer community. Look at our list of Alexa skills vs. our list of Google Home voice actions: Google is just getting started here. Google’s speaker also sounds better, and costs more, than Amazon’s hot-selling Echo Dot, putting it in a little more danger from Apple’s higher-end product.This doesn’t mean that Apple’s HomePod is going to be a best-seller. Sure, it could be the next Apple Hi-Fi, an expensive audio accessory that ends up being overlooked for better third-party products. But it keeps the waters roiled, and keeps the Google/Amazon duopoly from fixing in place. When developers can only focus on two platforms, that means at least Apple has a chance. This story originally appeared on PCMag With HomePod, Apple Just Wants to Shake Things Up (for Now) Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business Image credit: Apple via PC Mag Add to Queue 35shares Lead Mobile Analystcenter_img June 7, 2017 4 min read There’s room for two smart voice platforms; Apple just wants HomePod to be in second place. Register Now » Learn how to successfully navigate family business dynamics and build businesses that excel. Sascha Segan Applelast_img read more

Microsoft Launches New Effort to Bolster Its Startup Support

first_img June 26, 2013 Microsoft Launches New Effort to Bolster Its Startup Support Senior Entrepreneurship Writer at CNBC –shares 2019 Entrepreneur 360 List Catherine Clifford 2 min read The only list that measures privately-held company performance across multiple dimensions—not just revenue. Tech-behemoth Microsoft is making a move to be more startup friendly.The Redmond, Wash.-based software company announced Microsoft Ventures, an umbrella organization for its various entrepreneurship resources, according to a statement from Rahul Sood, the general manager of Microsoft Startups, on the official Microsoft blog. Microsoft has already provided software tools and resources to 75,000 startups since 2008 through its Biz Spark program and graduated more than 100 startups from its accelerator programs. The new effort will unify and bolster Microsoft’s mentorship, technology guidance, seed funding and joint selling opportunities to startups.Related: New York University’s Accelerator is Looking to Jump Start Startups“Startups have enough to worry about,” Sood says. “We want to make access to us as intuitive and friction-free as possible.”Microsoft Ventures will take a “holistic approach,” as a three-channel, global support system for startups including a seed fund, a handful of accelerator programs and a community of local experts. Microsoft will open new accelerators in Berlin, Moscow and Rio de Janeiro, adding to its existing programs in Bangalore, Beijing, Paris, Seattle and Tel-Aviv, says Sood. Also, the seed funding Bing Fund will grow, allowing Microsoft to provide early-stage funding to more startups.Related: Microsoft and Oracle Join Forces Against Smaller Rivals in Cloud  Add to Queue Next Article Technology Apply Now »last_img read more

Testa Analytical Solutions AYE Combo Refractometer Viscometer sets new standard

first_imgJan 29 2019The AYE Combo Refractometer / Viscometer from Testa Analytical Solutions e.K. sets a new standard for the detection of intrinsic viscosity of highly diluted samples. Source:https://www.testa-analytical.com/ This unique instrument is designed to have a high performance refractometer as an integral part of the viscometer, therefore both concentration and viscosity are measured at exactly the same time on the very same sample segment.Related StoriesTesta Analytical Solutions introduces new version of powerful Particle Solutions software suiteRevolutionary instrument for characterizing liposomes and liposome-drug conjugatesDynamic Light Scattering measurements in concentrated solutionsAs a consequence the AYE Combo Refractometer / Viscometer allows a much more accurate determination of molecular parameters and is particular suitable for applications focused on determining the structure and branching of complex polymers.Using a viscometer within a GPC/SEC System, requires a source of a concentration signal to complete the necessary calculations. The limitation of using a standard Differential Refractive Index (DRI) detector for this task, is that it must deliver a corresponding concentration signal for each point on the viscosity curve. This is possible with two separate instruments, precision of the results however, will be limited due to the volume difference of the detectors. A combination instrument, such as the AYE Combo, where both detectors are integral part of each other, overcomes these limitations and allows a much better determination of the sample under investigation.last_img read more

Diseasemodifying therapy for Alport syndrome still remains an unmet need

first_imgRelated StoriesNanotechnology-based compound used to deliver hepatitis B vaccineResearchers discover gene linked to healthy aging in wormsResearchers identify gene mutations linked to leukemia in children with Down’s syndromeAt present, there is no curative treatment for AS, so all males with X-linked disease and all males and females with ARAS, as well as a certain percentage of patients with ADAS, will ultimately show progression to ESKD. The only recommended treatment nowadays for this disease is RAAS (renin-angiotensin-aldosterone system) blockade. Currently RAAS is being tested in children even before the onset of proteinuria.Currently there is an ongoing trial using bardoxolone and another using anti miRNA21 is expected to start soon. Other drugs under study for AS are paricalcitol, lipid-lowering agents, epidermal growth factor receptor inhibitors, chaperones, stem-cell based therapies, inhibitors of STAT3, etc.”A specific disease-modifying therapy for AS remains an unmet need, but I am sure this will change, because AS has become a very attractive disease for pharmaceutical companies to target”, emphasizes Professor Torra and gives five reasons:(1) it is an excellent model of chronic kidney disease (CKD) with proteinuria and fibrosis that may be extrapolated to other more common causes of CKD;(2) any drug approved for this disease will have an orphan drug designation with its consequent benefits, such as shortened approval timeline, financial incentives, and a period of market exclusivity;(3) the number of patients to be treated will be substantial, AS being the second more frequent inherited kidney disease after ADPKD;(4) patients are young and have very few comorbidities, which facilitates clinical trials;(5) there is no approved treatment for ASSource:ERA-EDTAJournal reference:Torra, R & Furlano, M. (2019) New therapeutic options for Alport syndrome. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfz131. But similarly to other renal diseases, this is probably too late an endpoint to make a significant impact on the course of the disease. Theoretically, treatment prior to the appearance of renal fibrosis offers more promising long-term renal outcomes. GBM aspect and degree of fibrosis on renal biopsy as well as proteinuria could be excellent endpoints for clinical trials.”Professor Roser Torra, Barcelona/Spain, main author of the review published in NDT today Reviewed by Kate Anderton, B.Sc. (Editor)Jun 13 2019Alport syndrome (AS) is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. Depending on the mutated gene and the pattern of inheritance, there are three types of AS. Mutations in COL4A5 cause severe disease in males and a disease of variable severity (but usually much less severe) in females. Mutations in COL4A3 and COL4A4 are the cause of the autosomal forms of AS. Homozygous or compound heterozygous mutations in COL4A3 or COL4A4 are the cause of autosomal recessive AS (ARAS), while a single mutation in either of these genes causes autosomal dominant AS (ADAS).Having only one mutation in COL4A3 or COL4A4 can cause a phenotype that ranges from nothing (i.e. some parents of children with ARAS) to haematuria alone or to proteinuria and subsequent renal failure on top of haematuria. Over the past several years it has become increasingly apparent that more patients reach end-stage kidney disease (ESKD) due to ADAS than due to classical X-linked AS or ARAS, even though this progression occurs at a much older age. The seminal determinant of disease progression in AS logically seems to be the amount of damage in the glomerular basement membrane (GBM).A surrogate pathological marker may be tubulointerstitial fibrosis, which has been recognized as the key feature in progressive renal damage leading to ESKD. The glomerular disease and the podocyte stress response lead to the secretion and distribution of profibrotic chemokines and cytokines, which are the main causes of interstitial fibrosis and tubular atrophy. Progression from haematuria to microalbuminuria and progression from microalbuminuria to overt proteinuria represent very important steps in the course of AS. As for many renal diseases, the primary endpoint for AS clinical trials is or will be the decline in GFR.last_img read more

Lok Sabha elections 2019 Rahul Gandhi promises separate ministry for fishermen

first_imgpolitics Rahul Gandhi RELATED Focus will be on unemployment, job creation: Rahul SHARE SHARE EMAIL Published on COMMENT national elections SHARE Congress chief Rahul Gandhi on Thursday vowed to set up a separate ministry for fishermen if the Congress is voted to power in the Lok Sabha elections, saying unlike Prime Minister Narendra Modi he did not make “fake promises”.He was addressing the National Fishermen Parliament organised by All India Fishermen Congress in Thriprayar near here.“My commitment to you is that the moment we win the 2019 elections, all the fishermen of the country will get their own dedicated ministry in Delhi,” Rahul Gandhi said. Assuring the fishermen that he would fulfil the promise if the Congress wins, the Congress chief said, “I am not like Narendra Modi. I don’t make fake promises.” “Please look at my speeches. When I say something, I only say it because I have decided to do it,” he said. Rahul Gandhi. File photo   –  PTI March 14, 2019 COMMENTSlast_img read more

MamataModi war of words takes a turn for the worseMamataModi war of

first_imgWest Bengal Chief Minister Mamata Banerjee (file photo) COMMENTS SHARE The war-of-words between the Trinamool Congress and the BJP turned uglier with West Bengal Chief Minister Mamata Banerjee calling Prime Minister Narendra Modi, a “liar” and a “bad influence on youngsters”.Banerjee, who is known to be extremely critical of the Prime Minister, has previously called him “Hitler’s grandfather” and other names that include “expiry babu”.The attacks have even been personal to the extent that West Bengal Chief Minister said that “a man who cannot take care of his wife, will not be able to take care of the country either” (referring to Modi’s election affidavit and the controversy over his marriage). The sharpened attack on the Prime Minister came during one of Banerjee’s election rallies. “I have worked with many Prime Ministers. But, I have never seen a bigger liar than Modi. He is a bad influence for young minds,” she said in Purulia, 300 km from the city.Banerjee had previously made a veiled reference to Gujarat riots. “Today, you are calling me ‘tolabaaz’ (extortionist). If I am a tolabaaz, what are you? Your entire body, from head to feet, is drenched in blood. Only riots, riots and riots,” she had said. Modi had accused Banerjee and her party of being involved in extortion rackets and also ponzi scheme scams. The BJP has emerged the principal challenger to the TMC’s dominance in Bengal. With 42 Lok Sabha seats, the State holds the key to BJP’s hopes of improving its tally in the 2019 Lok Sabha. Published on political campaigns SHARE SHARE EMAIL May 07, 2019 COMMENTlast_img read more

Undocumented migrants storm Pantheon monument in Paris

first_img World 10 Jul 2019 Macron turns his sights on France’s town halls for power base Related News PARIS (Reuters) – Hundreds of undocumented migrants calling themselves “black vests” stormed the Pantheon monument in central Paris on Friday demanding the right to remain in France.Police on the scene told Reuters an estimated 200 to 300 protesters, mostly from West Africa, managed to get into the Left Bank mausoleum where national heroes including Voltaire and Victor Hugo are buried.”We will remain here until the last one of us has been given documents,” a leaflet given out by an organiser read. Young men were chanting “black vests” – a reference to the recent anti-government “yellow vest” protests – while marching around the monument, which is located in the heart of the capital’s Latin Quarter, an area popular with tourists. Related News About 50 to 60 riot police barricaded access to the site of the protest, which was taking place peacefully, and them out of the building in groups. Far-right leader Marine Le Pen called the occupation unacceptable. She tweeted: “In France, the only future for any illegal immigrant should be getting kicked out, because that’s the law.” (Reporting by Forrest Crellin; writing by Michel Rose; Editing by Richard Lough)center_img World 11h ago More bodies found in Tunisia migrant ship sinking feared to have killed more than 80 World 10h ago Italy court says Eritrean in migrant case was victim of mistaken identity {{category}} {{time}} {{title}}last_img read more