After a long wait, Xiaomi announced the most awaited flagship of the year – Mi 6 on April 19. Soon after the launch, the Xiaomi smartphone was made available for pre-orders for its first flash sale set for April 28. However, as of now, the handset will only be available in China. The smartphone has received over 10 lakh (1 million) pre-registration already on JD.com.The 1 million mark is based only on the number of pre-bookings on Jingdong (JD.com). However, the Chinese smartphone maker also has a tie up with a few other online retailers carrying out Mi 6 flash sale on April 28. So, if numbers are to be considered, the pre-registration number must have almost crossed 20 lakh (2 million) or even more by now. No confirmation has come on the pre-registration numbers from Xiaomi.Also Read: Xiaomi Mi 6: Full specs, price, features and everything else you need to knowXiaomi Mi 6 will be up for flash sale exclusively on JD.com, Giztop, and a few more online retail store in China on April 28. It is just another 4 days to go for the first flash sale for the Mi 6, and the pre-registration numbers are still increasing at a rapid pace. However, a previously leaked report revealed that Xiaomi will only be selling about 80,000 units approx, which means not all the users pre-registering the device will be able to get the device. This information is not confirmed by the company and the number of units may vary accordingly.As per the Chinese retail website — JD.com, the Xiaomi smartphone has already been booked by 1,108,192 consumers to be specific. The number is expected to increase, and this is because of the popularity that the smartphone started gaining ahead of its launch and also for the amazing features that it sports, especially the processor. Xiaomi Mi 6 is powered by Qualcomm’s latest octa-core Snapdragon 835 processor, which is also seen on the recently announced Samsung flagships – Galaxy S8 and S8 Plus.advertisementAlso Read: With Mi 6, Xiaomi brings iPhone 7 Plus camera technology to massesIn terms of specifications, Xiaomi Mi 6 features a 5.15-inch 1080p display and is powered by Qualcomm’s latest processor – the Snapdragon 835. Further, the smartphone comes with 6GB of RAM and is backed by a 3,350mAh battery. The Mi 6 is available in two storage variants – 64GB and 128GB. On the camera front, the smartphone features a dual camera setup at the rear with 12-megapixel wide-angle sensor, while on the front the device sports an 8-megapixel selfie snapper.As per the pricing, the Xiaomi Mi 6 comes in two variants – one with 6GB of RAM and 64GB of internal storage for CNY 2,499 (approximately Rs 23,500), while the higher-end variant with 6GB of RAM and 128GB of internal storage for CNY 2,899 (approximately Rs 27,000). There is no information on the Indian release as of yet. However, with the overwhelming response by the consumer, Xiaomi may very soon launch the Mi 6 globally. Also, the company is also rumoured to announce the Xiaomi Mi 6 Plus in the upcoming days.
TagsTransfersAbout the authorPaul VegasShare the loveHave your say Henrik Larsson linked with Southend jobby Paul Vegasa month agoSend to a friendShare the loveFormer Manchester United striker Henrik Larsson is being linked with a return to England.The Daily Mail says he has emerged as a target for Southend United.The League One side want to bring in the Swedish icon to replace Kevin Bond.The Shrimps side have been without a manager for two weeks.They remain winless this season in the league and lost 4-3 at Shrewsbury last night.They’ve lost seven and drawn one of their eight games so far this campaign.Larsson quit as Helsingborgs boss last month over the alleged level of “verbal insults” he received.
OFF TO THE POUND….A4 Audi estate car seized by police in Derry.THE police in Derry would like a quiet word with the owner of this Audi A4 car which was found abandoned on a bad bend and blocking a farmer’s property.PSNI Foyle say on its Facebook page: “Could the owner of this Audi A4 estate which was left for a considerable period of time on the Beragh Hill Road, make contact with Constable Brogan of Ballyarnett NPT at Strand Road PSNI Station ASAP.“We would like to know why it was parked blocking a farmers property, was on a bad bend, had a number of dodgy tyres, was full of empty tins of alcohol and had a bong in the rear seat. “It’s also showing no insurance and was found on a public road.“We have seized it for now and happy to discuss it with the owner if located.“Police checks regarding the owner have been inconclusive thus far.”POLICE KEEN TO TRACE ‘INCONSIDERATE’ OWNER OF THIS ABANDONED AUDI CAR was last modified: January 6th, 2018 by John2John2 Tags: ShareTweet BERAGH HILL ROADCONSTABLE BROGANPOLICE KEEN TO TRACE ‘INCONSIDERATE’ OWNER OF THIS ABANDONED AUDI CARPSNI FOYLE
Related StoriesNanotechnology-based compound used to deliver hepatitis B vaccineResearchers discover gene linked to healthy aging in wormsResearchers identify gene mutations linked to leukemia in children with Down’s syndromeAt present, there is no curative treatment for AS, so all males with X-linked disease and all males and females with ARAS, as well as a certain percentage of patients with ADAS, will ultimately show progression to ESKD. The only recommended treatment nowadays for this disease is RAAS (renin-angiotensin-aldosterone system) blockade. Currently RAAS is being tested in children even before the onset of proteinuria.Currently there is an ongoing trial using bardoxolone and another using anti miRNA21 is expected to start soon. Other drugs under study for AS are paricalcitol, lipid-lowering agents, epidermal growth factor receptor inhibitors, chaperones, stem-cell based therapies, inhibitors of STAT3, etc.”A specific disease-modifying therapy for AS remains an unmet need, but I am sure this will change, because AS has become a very attractive disease for pharmaceutical companies to target”, emphasizes Professor Torra and gives five reasons:(1) it is an excellent model of chronic kidney disease (CKD) with proteinuria and fibrosis that may be extrapolated to other more common causes of CKD;(2) any drug approved for this disease will have an orphan drug designation with its consequent benefits, such as shortened approval timeline, financial incentives, and a period of market exclusivity;(3) the number of patients to be treated will be substantial, AS being the second more frequent inherited kidney disease after ADPKD;(4) patients are young and have very few comorbidities, which facilitates clinical trials;(5) there is no approved treatment for ASSource:ERA-EDTAJournal reference:Torra, R & Furlano, M. (2019) New therapeutic options for Alport syndrome. Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfz131. But similarly to other renal diseases, this is probably too late an endpoint to make a significant impact on the course of the disease. Theoretically, treatment prior to the appearance of renal fibrosis offers more promising long-term renal outcomes. GBM aspect and degree of fibrosis on renal biopsy as well as proteinuria could be excellent endpoints for clinical trials.”Professor Roser Torra, Barcelona/Spain, main author of the review published in NDT today Reviewed by Kate Anderton, B.Sc. (Editor)Jun 13 2019Alport syndrome (AS) is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. Depending on the mutated gene and the pattern of inheritance, there are three types of AS. Mutations in COL4A5 cause severe disease in males and a disease of variable severity (but usually much less severe) in females. Mutations in COL4A3 and COL4A4 are the cause of the autosomal forms of AS. Homozygous or compound heterozygous mutations in COL4A3 or COL4A4 are the cause of autosomal recessive AS (ARAS), while a single mutation in either of these genes causes autosomal dominant AS (ADAS).Having only one mutation in COL4A3 or COL4A4 can cause a phenotype that ranges from nothing (i.e. some parents of children with ARAS) to haematuria alone or to proteinuria and subsequent renal failure on top of haematuria. Over the past several years it has become increasingly apparent that more patients reach end-stage kidney disease (ESKD) due to ADAS than due to classical X-linked AS or ARAS, even though this progression occurs at a much older age. The seminal determinant of disease progression in AS logically seems to be the amount of damage in the glomerular basement membrane (GBM).A surrogate pathological marker may be tubulointerstitial fibrosis, which has been recognized as the key feature in progressive renal damage leading to ESKD. The glomerular disease and the podocyte stress response lead to the secretion and distribution of profibrotic chemokines and cytokines, which are the main causes of interstitial fibrosis and tubular atrophy. Progression from haematuria to microalbuminuria and progression from microalbuminuria to overt proteinuria represent very important steps in the course of AS. As for many renal diseases, the primary endpoint for AS clinical trials is or will be the decline in GFR.
COMMENTS COMMENT April 16, 2019 Published on Electoral politics in Bengaluru — the tech city that contributes around $50 billion or 40 per cent of India’s total IT exports — is increasingly being shaped by citizen activism.The city has three urban Parliamentary constituencies — Bangalore North, Bangalore Central, Bangalore South, and one semi-urban constituency — Bangalore Rural.In the last two decades, citizen activism has percolated to all levels of political discourse and governance, be it the civic body (BBMP), the State Assembly or Parliament.The large-scale migration experienced by the city in the last two decades has led to the crumbling of civic infrastructure. The citizens’ involvement has changed electoral politics in the city with numerous agitations — ‘Steel Bridge Beda’, ‘Circular Railu Beku’, ‘Footpath Beku’, ‘Save Trees’, ‘Save Lakes’, especially the Bellandur lake.The organisations heading the activism are ‘Whitefield Rising’ and ‘Citizens for Bengaluru’ which have taken the discourse from social media to the streets. In fact, the previous government scrapped the steel flyover proposal just before the Assembly elections.‘A positive effect’In the absence of vote-bank politics in the city, the Resident Welfare Association (RWA) is playing a pivotal role in the formulation or shaping public policies, especially garbage clearance, traffic regulation and regulation of commercial spaces in residential layouts. Rekha Chari, former president, Malleswaram Swabhimana Initiative (MSI) said, “Citizen activism in Bengaluru is on the rise and impacting the city in a positive way. We interact regularly with our elected representatives, be it the MLA, corporator or MPs, to get our problems solved.“We had come out with a citizen manifesto during the Assembly election and, today, many parties and candidates have included points from that,” she added. Candidates now are relying on the performance and popularity of local corporators and MLAs. In the 2018 Assembly election, the city witnessed a shift of urban votes to the Congress, which has worried the BJP. SHARE SHARE SHARE EMAIL state politics Bengaluru
Published on NBFC July 10, 2019 Press Trust of India Bengali film actor Rituparna Sengupta has been summoned by the Enforcement Directorate next week in connection with the investigation into the Rose Valley ponzi scam, a day after it summoned superstar Prosenjit Chatterjee in the same case. According to the sources, Sengupta allegedly accompanied Rose Valley group chairman Gautam Kundu on several foreign trips and helped him in the sale and production of films. “We have summoned actor Rituparna Sengupta in connection with the Rose Valley scam. She has been asked to appear next week,” ED sources told PTI. Phone calls made to Sengupta for her reaction went unanswered. Chatterjee, meanwhile, had been asked to depose before the ED officials at the CGO Complex office in Salt Lake on July 19. The Tollywood actor’s statement will be recorded under the Prevention of Money Laundering Act (PMLA). The sources said the agency wanted to question Chatterjee about ₹2.75 crore received by his company, Idea Locations and Production Pvt Ltd, from the Rose Valley group between 2010 and 2011. Of this, Chatterjee is suspected to have received about ₹23.5 lakh. The probe agency wants to understand the purpose of these funds, they claimed. Chatterjee has acted in several films produced and distributed by Rose Valley, notable among them being Moner Manush and Hangover. A probe by the agency has revealed that Rose Valley, on paper, undervalued the film’s production cost and used depositors’ money to fund Hangover, the ED sources added. The ED had on Monday interrogated senior Trinamool Congress leader Madan Mitra in connection with the ponzi scam. SHARE COMMENT West Bengal SHARE SHARE EMAIL economic offence COMMENTS
India Today Web Desk New DelhiJuly 13, 2019UPDATED: July 13, 2019 11:38 IST Robert Vadra, brother-in-law of Congress leader Rahul Gandhi has posted a heartfelt note for him on Facebook. (Image: PTI)Robert Vadra, brother-in-law of Congress leader Rahul Gandhi has posted a heartfelt note for him on Facebook, praising him for being a youth icon.He also thanked him for being a great example of moral character and willpower for him. He ended the note by saying that he extends his support to him and that no position is required to for social service.He stated, “There is so much to learn from you, Rahul. The Indian populace, which comprises 65 per cent of the young – (under 45 years), looks up to you and other young leaders for direction.” Meanwhile, amid the ongoing Karnataka crisis, Congress leader Rahul Gandhi on Friday claimed that the Bharatiya Janata Party (BJP) uses “money power” and “intimidation” to topple governments. He accused the saffron party of doing the same in Karnataka.Sixteen MLAs have resigned and two independents have withdrawn support to the 13-month-old Congress-JD(S) coalition government in Karnataka.”BJP uses money power or threat to topple governments wherever it can. You saw this first in Goa, in the Northeast, and now are trying to do the same in Karnataka. It is their way of functioning. They have money, power, and they use it. This is the reality,” Gandhi told reporters.Also read | BJP toppling govts with money power, threats: Rahul GandhiAlso read | Rahul Gandhi granted bail in Ahmedabad bank defamation case on Rs 15,000 bondAlso watch | Nataka in Karnataka: Rahul Gandhi breaks his silence, says BJP using money power to topple govtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi Tags :Follow Robert VadraFollow Rahul Gandhi Next Robert Vadra praises Rahul Gandhi for being a youth iconRobert Vadra ended his note by saying that he extends his support to Rahul Gandhi and that no position is required to for social service.advertisement