15 total views, 1 views today AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis Tagged with: Digital AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to LinkedInLinkedInShare to EmailEmailShare to WhatsAppWhatsAppShare to MessengerMessengerShare to MoreAddThis Howard Lake | 2 September 2008 | News Blue Cross launches social network for pet lovers Pet Charity The Blue Cross has created a new social network for pet lovers. ‘All About Pets’is designed to “give pet lovers a new way to communicate and share experiences or advice about their pets”.The site was built by digital agency DVA and is designed to appeal to pet lovers around the world.Built by digital agency DVA, the site has attracted over 450,000 unique visits from 142 countries since its beta launch in March this year, with more than 6,800 people registering.Part of the promotion campaign for All About is an online viral campaign which allows users to send personalised talking pets to their friends. Launched at the end of July, the viral has been viewed over 100,000 times.Laura Dobson, spokesperson for All About Pets said: “As one of the UK’s oldest animal charities, The Blue Cross has a wealth of experience in pet care. But we also recognise that there are many pet owners out there with their own unique experiences to share. All About Pets is a fun, informative and entertaining website where pet lovers can go to meet like-minded people and celebrate the joys of pet ownership. In time, we hope it will become the place to go to talk and learn about pets.”Although there are plenty of other websites and social networks catering for animal and pet lovers, The Blue Cross believes that its site has an advantage. With 110 years of experience with animals and pets the charity is using the site to offer an authorative and reliable information resource on pet care advice. More than 80 leaflets on all aspects of animal care are available to view, print or download free from the site.All the services on All About Pets are available at no charge. Members can create profiles for themselves and their pets, upload photos or links to videos and showcase their pet’s talents. They can also view other people’s pets, photos and videos and even rate them. Members can take part in discussion forums and polls on topical subjects, promote their own events or find out what is happening in their area, and get the latest pet news.www.allaboutpets.org.uk About Howard Lake Howard Lake is a digital fundraising entrepreneur. Publisher of UK Fundraising, the world’s first web resource for professional fundraisers, since 1994. Trainer and consultant in digital fundraising. Founder of Fundraising Camp and co-founder of GoodJobs.org.uk. Researching massive growth in giving.
Pinterest Local NewsBusiness Positive BNC210 7-Day Dosing Pharmacokinetic Study Exceeds Blood Exposure Projected for Phase 2b PTSD Trial WhatsApp Twitter TAGS Facebook WhatsApp BNC210 novel oral tablet formulation (900 mg given twice daily) exceeds blood exposure projected for upcoming Phase 2b PTSD trialBNC210 Phase 2b PTSD trial on target for start in mid-2021 with final dose selected ADELAIDE, Australia, Feb. 22, 2021 /PRNewswire/ — Bionomics Limited (ASX: BNO, OTCQB: BNOEF, Germany: AU000000BNO5), a global, clinical stage biopharmaceutical company, today announced positive pharmacokinetic (PK) results from a 7-day dosing study in healthy volunteers using the newly developed solid dose oral tablet formulation of BNC210. BNC210 is a novel, negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in development for the treatment of anxiety and stressor-related disorders, and in November 2019 was granted Fast Track designation by the US Food and Drug Administration (FDA) for the treatment of Post-Traumatic Stress Disorder (PTSD). The 7-day dosing PK study in ten healthy volunteers (females and males) demonstrated that at a dose of 900 mg given twice daily, the tablet formulation of BNC210 had steady-state 12-hourly exposure levels ranging from 33-57 mg.h/L which exceed the 12-hourly blood exposure of ~25 mg.h/L predicted as necessary to meet the primary endpoints for effectiveness for treating PTSD patients in future clinical trials. A pharmacometric analysis of data from the first Phase 2 PTSD trial (RESTORE) that read out in October 2018, modelled an exposure-response relationship between BNC210 blood levels and CAPS-5 scores (the primary endpoint measure in PTSD trials), and the potential for BNC210 to treat PTSD symptoms provided that adequate blood exposure could be achieved. The tablet formulation of BNC210 replaces the liquid suspension formulation used in RESTORE which did not provide sufficient blood exposure for efficacy in that Study. The BNC210 tablet will be easier for the PTSD trial participants to administer and, unlike the liquid suspension formulation, is not dependent on food intake for maximal absorption and is therefore expected to result in substantially less variable exposure in the patients in the next Phase 2b PTSD study. Furthermore, the recent PK results show that there is no gender-based difference in exposure and that BNC210 continues to be well-tolerated, even at the higher exposure levels achieved after 7 days of dosing in the healthy volunteers. Dr. Errol De Souza, Executive Chairman of Bionomics said, “We are extremely pleased with the results of the 7-day PK study which demonstrate that we reach steady-state levels on the second day following the start of twice daily dosing and that we not only meet but exceed the blood exposure predicted from the pharmacometric analysis as necessary for future trials. With the dose now selected, we can initiate manufacturing of the tablets, clinical site selection and regulatory filings in preparation for a Phase 2b trial with BNC210 in PTSD patients projected for mid-2021. The recently oversubscribed Private Placement of approximately $16 million along with the proposed Entitlement Offer to our current shareholders will provide us with the funds necessary for BNC210 development.” AUTHORISED BY THE BOARD OF DIRECTORS About Bionomics Limited Bionomics (ASX: BNO, OTCQB: BNOEF, Germany: AU000000BNO5) is a global, clinical stage biopharmaceutical company leveraging its proprietary platform technologies to discover and develop a deep pipeline of best in class, novel drug candidates. Bionomics’ lead drug candidate BNC210, currently in development for initiation of a second Phase 2 trial for the treatment of PTSD, is a novel, proprietary negative allosteric modulator of the alpha-7 nicotinic acetylcholine receptor. Beyond BNC210, Bionomics has a strategic partnership with Merck & Co., Inc (known as MSD outside the United States and Canada) with two drugs in early stage clinical trials for the treatment of cognitive deficits in Alzheimer’s disease. www.bionomics.com.au Factors Affecting Future Performance This announcement contains “forward-looking” statements within the meaning of the United States’ Private Securities Litigation Reform Act of 1995. Any statements contained in this announcement that relate to prospective events or developments, including, without limitation, statements made regarding Bionomics’ drug candidates (including BNC210), its licensing agreements with Merck & Co. and any milestone or royalty payments thereunder, drug discovery programs, ongoing and future clinical trials, and timing of the receipt of clinical data for our drug candidates are deemed to be forward-looking statements. Words such as “believes,” “anticipates,” “plans,” “expects,” “projects,” “forecasts,” “will” and similar expressions are intended to identify forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by these forward-looking statements, including unexpected safety or efficacy data, unexpected side effects observed in clinical trials, risks related to our available funds or existing funding arrangements, our failure to introduce new drug candidates or platform technologies or obtain regulatory approvals in a timely manner or at all, regulatory changes, inability to protect our intellectual property, risks related to our international operations, our inability to integrate acquired businesses and technologies into our existing business and to our competitive advantage, as well as other factors. Results of studies performed on our drug candidates and competitors’ drugs and drug candidates may vary from those reported when tested in different settings. View original content: http://www.prnewswire.com/news-releases/positive-bnc210-7-day-dosing-pharmacokinetic-study-exceeds-blood-exposure-projected-for-phase-2b-ptsd-trial-301232333.html SOURCE Bionomics Limited Pinterest Twitter Previous articleIn Israel and beyond, virus vaccines bring political powerNext articleJuniper Research: Smart Traffic Management to Significantly Reduce Congestion and Emissions; Saving Cities $277 Billion by 2025 Digital AIM Web Support Facebook By Digital AIM Web Support – February 22, 2021
LONDON (AP) — Ten years after protests rocked Egypt, many of the participants live in exile. They have fled to Europe and beyond out of fear for their personal safety under President Abdel Fattah el-Sissi, who continues a crackdown on the political opposition. The Jan. 25, 2011, uprising in Tahrir Square led to the quick ouster of autocratic President Hosni Mubarak. But events did not turn out the way the protesters had envisioned, leading to an even harsher successor in el-Sissi, who has jailed journalists, human rights activists and others. Thousands of academics, artists, writers and other intellectuals have fled their homeland, some never to return.
2SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Andrea Parrish With over 20 years of communications and digital media experience, Andrea Parrish has lived in many worlds. She’s been a successful Kickstarter-funded small business owner, speaker on hundreds of conference … Web: andreaparrish.com/tinytall-consulting Details Digital marketing as we know it is on its last legs, and it’s up to credit union marketers to start preparing now for the big opportunity this presents. It’s only a matter of time before changes being implemented by tech giants upend the focus of digital marketing. Credit unions, as trusted educators and partners, however, are particularly well-suited to make use of this change. The cookies are going stale In 2019, Mozilla and Apple both announced that they would be ending support for third-party tracking cookies. In January of this year, Google put a two-year expiration date on its support of third-party cookies. Within the next few years, just about every major browser will also close the loopholes that allow marketers to get around these changes. Because they rely on tracking cookies, this all means that digital marketing based on targeting, retargeting, display advertising, and behavioral marketing will all be shifting significantly. Members didn’t want the cookies anywayAccording to DemandMetric’s 2019 research, even those individuals who don’t yet block cookie-based ads still want something else. 70% of people prefer to learn about an organization through non-advertising content. It’s the classic game of advertising cat-and-mouse… when a platform gets too packed with ads, content consumers go elsewhere, and the advertising eventually follows. The difference today is that the internet isn’t going anywhere, but how we interact with it is changing. For credit unions, these changes have two big impacts. We’ll need to dig deep into our own data to engage existing members differently, and focus on executing a strong integrated content strategy to attract new members. A new recipe for member engagementEven though third-party tracking data is being limited, first-party data will (for now) still be allowed in digital marketing. As a financial institution, you have access to a massive amount of first-party data, all connected to specific members and households. If you have not yet ensured that you have that data structured in a way you can access it, now is the time to start. Behavioral marketing is going to be the name of the game here — building out if/then triggers based on how your members behave. Is an indirect member 3 months away from paying off their car loan? Why not encourage them to set up a savings account for vehicle maintenance and deposit what their payment would have been? Is it March of a 17 or 18-year old member’s school year? How about sending them information on keeping their accounts at your CU, even if they move away for college or to explore the world? Even better, start the conversations with your Compliance department now about if you can upload the email addresses of these members to digital advertising outlets to target ads to them using your first-party data, instead of third-party tracking. At the same time, ensure that your frontline team all has access to this information and a way to quickly understand it, so they can start these conversations with members naturally. Non-cookie content rules acquisitionAll this behavioral data is great for members you already have data on, but how about those bank customers in your market that really need to experience the credit union difference? According to one 2020 survey, 70% of all marketing professionals are already increasing their investment in content marketing — and for good reason. Content marketing provides information and names your credit union as a trusted resource, which means that when people have financial questions, they already know who to approach for answers. It’s an opportunity credit unions haven’t been taking full advantage of. While 93% of marketers across industries report that they have at least thought about an integrated content strategy, over 50% of financial marketers say that it’s not really on their radar. Additionally, financial institutions report doing more “ad hoc” content creation than the average business. In other words, we know content is important, but feel like we don’t have the resources or time to make the best use of it. Credit unions have a huge advantage here, though. One of the seven cooperative principles is education, after all, and as a not-for-profit organization, we’ve instantly got more credibility. Just about every credit union is already creating something that could be the basis of a content marketing strategy. Rather than trying to build an integrated content plan from scratch, most credit unions can start by mining the articles, blogs, videos, classes, letters, conversations, or even just office discussions that already exist in their (digital or in-person) hallways, and using that content on their social media, websites, and existing distribution outlets. Once you’ve started that wheel rolling, it’s much easier to build content marketing partnerships, add additional paid outlets, or pitch your content to new outlets. Long live digital outlets The death of the third-party tracking cookie has been a long time coming, and won’t happen quickly. Members and potential members, however, are savvy. It’s likely that long before the cookie is officially as dead as Adobe Flash-based websites, smart marketers will move their efforts away from marketing tactics that rely on those cookies. With a wealth of data at our fingertips and a cooperative business model that naturally encourages content that just needs to be captured, rather than created from scratch, credit unions have a big opportunity to make the best of this shift.
Volunteers get busy with the spring cleanup at Riverside Gardens Park. Photo by John Burton RED BANK — The mild weather has people thinking about gardening. That’s true for Rumson residents Bob and Karen Hespe. But the garden on their minds, and those of a handful of other volunteers, isn’t their own, but the one in Riverside Gardens Park.As they have done for the past few years, the Hespes will be caring for more than 200 rose bushes planted in the park overlooking the Navesink River.They, some of their friends and members of Rumson Boy Scout Troop 201, were on hand at the park last Saturday morning, to begin this year’s work of clearing, prining and preparing for some additional plantingt.“I was taking a walk through here,” Hespe recalled, “and we saw how much work had to be done here.”The park, which the borough constructed about a dozen years ago, is used in the warmer months for concerts and community events. The community also uses the park for recreation, weddings, photo shoots and school graduations.The park has won awards for its design, but the Hespes long felt that the plantings in the park could use a little TLC.“We spend so much time here,” Karen said, “It’s a nice place to come for a walk and it should look beautiful.”Bob contacted Memone Crystian, the borough’s parks and recreation director requesting permission to care for the plantings and the director gave her permission.Last year the Hespes and their fellow volunteers visited the park to care for the plantings 12 times, he said.Last Saturday they arrived at the park around 9 a.m. to start th spring cleanup.“We just dug and dug and dug out vines and weeds,” Hespe said.The volunteers concentrated on the park’s 240 rose bushes, trimming them a little and cleaning the beds. Thankfully, Bob Hespe explained, rose bushes are pretty hardy. “They need that first hit,” with some pruning, he said, then, “they do their thing.”“We focused just on the roses,” Karen added, “but there are a lot of things growing here and need work.”They would know — the Hespes operate a modest gardening and landscaping business.Sickles Market, Little Silver, donated a few hundred daffodil bulbs for planting in the park, and Bob Hespehopes that after this initial work the garden area will be in good enough shape to need only a once-a-month cleanup. They are hoping to find some additional volunteers to assist their current crop of helpers. “I know it’s a lot of work,” Karen acknowledged, “but it’s so much fun here and so many enjoy it, that it is really satisfying. But we could use more people.”
QPR – without a win or even a goal in their previous three matches – went behind to Theo Robinson’s goal three minutes before the break.Niko Kranjcar had their best chance during a first half in which they lost Junior Hoilett to injury.Hoilett limped off in the 12th minute at Loftus Road, where Doncaster belied their lowly position – and the wet and windy conditions – by causing problems with their slick passing and movement.Charlie Austin, back in the Rangers side following a hamstring problem, had a header from Joey Barton’s right-wing cross well saved by goalkeeper Ross Turnbull.And when Danny Simpson’s low cross fell to Kranjcar, the Croatian shot wide of the target.Rovers have been a threat on the counter attack, with Mark Duffy just failing to connect with Robinson’s cross and Richie Wellens shooting narrowly wide after jinking his way into the box.The visitors’ deserved breakthrough came when Yossi Benayoun, making his home debut, was robbed by Federico Macheda, who sent Robinson through for the striker to fire into the bottom corner.QPR: Green; Simpson, Onuoha, Dunne, Assou-Ekotto, Barton, Kranjcar, Hoilett (Phillips 12), O’Neil, Benayoun, Austin.Subs: Murphy; Traore, Hill, Johnson, Carroll, Henry.Follow West London Sport on TwitterFind us on Facebook
MESA, Ariz. — The A’s are taking it easy with one of their most valuable bullpen arms.Reliever Joakim Soria is dealing with right hip tendonitis and was held back from any hard-throwing activities during Tuesday’s workouts.“We’ll just see how he feels today after playing catch,” A’s manager Bob Melvin said. “It’ll probably be a couple of days and then see if we can get him off the mound.”Signed to a two-year deal in the offseason, Soria brings closing experience to the club having saved 220 …
Tags:#music#web 4 Keys to a Kid-Safe App 9 Books That Make Perfect Gifts for Industry Ex… brian proffitt The ongoing tug-of-war between musicians, record labels and digital content providers inched a little more towards artists this week with the introduction of an innovative paid-referral plan from streaming provider Rdio. The new program pays artists a flat $10 fee for every user they refer, a rare form of direct-to-artist revenue in the music streaming business. But it’s only the latest move to renegotiate the flow of money in the world of digital music – and now even Congress is weighing in.Rdio’s artist program is trying to play to both artists’ vanity and their pocket books. Not only will musicians get an immediate benefit for any new subscriber that joins Rdio, if they can help boost Rdio’s current 10-million-user subscriber base to challenge Spotify’s reported 33 million users, that should also increase overall payments to artists from royalties down the road. Of course, other than that up-front fee, Rdio’s royalty payments won’t provide much padding for musicians’ wallets, primarily because Rdio, like competing services Spotify and MOG, pays royalties directly to the record labels, not to the artists.Where The Streaming Music Money GoesAll three of these services essentially negotiate their royalty rates with the record labels in the same way – directly – which can take forever. Royalty arguments actually delayed Spotify’s entrance into the U.S. market by two years, and according to Casey Rae, co-director of the Future of Music Coalition, the three major U.S. labels ended up taking an equity stake in Spotify to make sure they could squeeze every last drop of juice from the service provider.Since these deals are private, it is not known how much each service has to pay to individual labels. It is estimated that Spotify pays anywhere from 70% to 97% of its subscription-based revenue to music distributors, depending on who you ask.Pandora, on the other hand, handles things differently, Rae emphasized in a recent interview. “Pandora can play anything it wants,” he explained. “Their license is a statutory license that pays the artist directly.” The royalty is split down the middle with a music label if the artist is signed with one.That rate, as the law proscribes, amounts to over 50% of Pandora’s revenue. As a non-interactive music streaming service, Pandora has to pay the highest rate bracket within the statute, far higher than satellite or cable TV providers have to pay for their music streaming services. Broadcasters, meanwhile, don’t have to pay anything, unless they stream their content on the Internet, at which point they have to pay the same rates as a service like Pandora or Clear Channel.The Laws of the LandTwo bills now in Congress are set to adjust the rate schedule for these services toward what could be more fair treatment of the streaming services.First is the Internet Radio Fairness Act of 2012, which would adjust the royalty rate that music streaming services have to pay down to match the levels that cable/satellite providers pay. Broadcast stations still pay nothing.Second is the Interim Fairness in Radio Starting Today Act , which takes the opposite approach and would increase the cable/satellite provider rate to match that of the streaming providers’ – and remove the exemption for broadcasters.Needless to say, artists and record labels are much more excited about the latter bill. The music industry already complains about how little it receives from streaming broadcasters, and undoubtedly would express outrage at any reduction in royalty rates.The Last Song A service like Pandora, which has to scale up its royalty payments as more subscribers join, is already dealing with the clash between revenues it generates and the royalties it has to pay. Without a reduction in statutory payments, it is not clear how long Pandora will continue to operate.Rdio, Spotify and MOG, since they have negotiated deals with the content providers separately, would be unaffected by either of these bills passing into law. But they can’t take on much more royalty payments either. Spotify alone lost $57 million in 2011, even as it pulled in $236 million in revenue.It’s a complex, contentious issue, but unless the the royalty issues get worked out, the future of Rdio and its streaming music competitors is in jeopardy. If it costs more for them to license the music they stream than the revenue they can generate from it, they won’t stay in business long. But if they raise prices dramitically to cover royalty payments, they risk losing subscribers who can’t justify the higher fees. And as usual, you can bet that the artists, not the music companies or streaming services, will be last in line to get paid.Image courtesy of Shutterstock. 5 Outdoor Activities for Beating Office Burnout Related Posts 12 Unique Gifts for the Hard-to-Shop-for People…
E.T. returns to earth, reunites with grown-up Elliott in new ad LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary SEA Games in Calabarzon safe, secure – Solcom chief Catriona Gray spends Thanksgiving by preparing meals for people with illnesses LATEST STORIES View comments WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding Playing like their campaigns were on the line, Arellano and Perpetual Help hacked out thrilling overtime victories over higher-ranked foes last Thursday to muddle up the Final Four race of NCAA Season 93 at Filoil Flying V Centre in San Juan.ADVERTISEMENT UPLB exempted from SEA Games class suspension LOOK: Venues for 2019 SEA Games Caron Butler remains close to the game even after a year out of the NBA MOST READ Nicholls finished with only five points but his triple could just be the shot that might save the Chiefs’ season after they improved their record to 4-6 in a tie for seventh spot with the Altas.“It’s a special skill, making that shot,” Codiñera said of Nicholls.Kent Salado also made an impact with 17 points, seven assists and three rebounds for Arellano, which put to waste JRU gunner Tey Teodoro’s 30-point explosion.The Altas looked like a rejuvenated crew as they rolled past the Knights in the extra period. Quiet for majority of the first round, Dagangon came alive with 21 points to match teammate Prince Eze’s output. Eze, the MVP race leader, also grabbed 19 rebounds.Perpetual also got solid games from GJ Ylagan, AJ Coronel and Kieth Pido, who combined for 37 points. But it was Dagangon who made the biggest shots, hitting two straight baskets for an 82-77 advantage.Coronel and Eze sealed the win with free throws after the Knights came within 82-85 with 25 seconds left.ADVERTISEMENT Read Next Getting a timely explosion from Gab Dagangon, the Altas turned back the Letran Knights, 88-82, in overtime to move within a game off the Top Four.Not to be outdone, the Chiefs also played with a sense of urgency to overcome the Jose Rizal Heavy Bombers, 115-109, in double overtime.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutZach Nicholls nailed a desperation trey to send the game into a second overtime before Allen Enriquez, Kraniel Victoria and Archie Concepcion finished off the fading Bombers, who remained in third spot despite falling to 6-4.“I guess it was the stops that made it,” said coach Jerry Codiñera. “Other than that prayer shot of Zach, we were really down. But we were able to regroup and we got energy from our bench.” Brace for potentially devastating typhoon approaching PH – NDRRMC NCAA Season 93 Preview: Perpetual Help Altas PLAY LIST 03:32NCAA Season 93 Preview: Perpetual Help Altas03:06‘Pamana’: Mausoleum caretaker cherishes humble work for family02:12San Beda, Lyceum early favorites ahead of NCAA Season 9301:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Don’t miss out on the latest news and information. “The team just showed a lot of heart,” said Perpetual coach Jimwell Gican. “We knew we still have a chance of making the Final Four.”
About the authorPaul VegasShare the loveHave your say Chelsea No2 Zola: Ampadu has very important future hereby Paul Vegas10 months agoSend to a friendShare the loveChelsea No2 Gianfranco Zola admits they’re delighted with the progress of Ethan Ampadu.Ahead of facing FA Cup opponents Nottingham Forest today, Zola discussed the teen.Ampadu committed his future to Stamford Bridge in September with a new five-year deal and assistant manager Zola stated he is highly rated at the club.The Blues legend said: “Ampadu is… when we spoke about Ampadu, me and a lot of staff, everybody shares the same opinion: he’s going to become an important player for this club.”He has intelligence, he has attitude. He has all the, in my opinion, qualities to become a top player. As a staff we value him a lot and when there is an opportunity he will get time.”